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The genetic instability underlying neoplastic transformation can also provide tumor-specific targets for host T cells (1–4).These include function-altering mutations in so-called “driver” genes, which endow the tumor with growth and survival advantages, as well as tumor-specific variants of “passenger” genes that lack an obvious protumorigenic …

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Depending on the cancer, splicing neoantigens often appear to be the dominant source of tumor-specific peptides (15, 16).Such splicing events include intron retention, which typically results in nonsense-mediated decay but which produces major histocompatibility complex (MHC)–presented neopeptides that …

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